Palliative mastectomy is by means to prevent and palliate breast or chest symptoms, or pain in order to allow patients to resume an active lifestyle as symptomless as possible with the fewest possible adverse effects of the treatment [2].

A couple of decades ago, Palliative Mastectomy for locally advanced breast cancers was a common, if not a frequent surgical procedure in the surgical armamentarium. The advent of a better understanding of tumor biology and better multidisciplinary management has certainly narrowed down its role. However, there are situations where it is still a potent option. In the subset of patients where the palliative mastectomy is to be performed, it is important to aim for clear surgical margins, with good clearance at the third dimension, i.e. the tumor base. Surgeons with adequate experience of breast cancer surgeries should perform the procedure to achieve intended palliation.